Evorel belongs to a group of medicines called HRT (hormone replacement therapy). Evorel contains the active ingredient Oestrogen (Estradiol) which is a female hormone. It comes in 4 different sizes Evorel 25, Evorel 50, Evorel 75 & Evorel 100. The hormone is spread evenly in each patch & slowly passes into your body through your skin. Evorel is used for the symptoms of the menopause & can also be used to prevent Osteoporosis (Fragile Bones) in women who have had the menopause & are most likely to have bone problems. Evorel, 50, 75 & 100 are only used if other medicines for Osteoporosis have been tried first & they have not worked. Evorel works by replacing the Oestrogen which is normally released by the ovaries. However in women who still have a womb, taking an oestrogen hormone regularly may cause the lining of your womb to build up & get thicker. This means it is necessary to add a progestogen hormone to the oestrogen. This helps shed the lining of the womb & stop any problems happening.